| Bayer Leverkusen – RB Leipzig |
20. Sep 13:30 |
| RB Leipzig – Eintracht Frankfurt |
10. Oct 16:30 |
| RB Leipzig – PSV Eindhoven |
13. Oct 19:00 |
| Bayern München – RB Leipzig |
17. Oct 16:30 |
| Real Madrid – RB Leipzig |
21. Oct 19:00 |
| RB Leipzig – SV Elversberg |
24. Oct 13:30 |
| FC Schalke 04 – RB Leipzig |
31. Oct 14:30 |
| RB Leipzig – Manchester City |
04. Nov 20:00 |
| RB Leipzig – FC Augsburg |
07. Nov 14:30 |
| Union Berlin – RB Leipzig |
21. Nov 14:30 |
| RB Leipzig – Lens |
24. Nov 20:00 |
| SC Freiburg – RB Leipzig |
28. Nov 14:30 |
| RB Leipzig – FSV Mainz 05 |
05. Dec 14:30 |
| Manchester United – RB Leipzig |
08. Dec 20:00 |
| 1. FC Köln – RB Leipzig |
12. Dec 14:30 |
| RB Leipzig – Borussia Dortmund |
19. Dec 14:30 |
| SC Paderborn 07 – RB Leipzig |
09. Jan 14:30 |
| RB Leipzig – VfB Stuttgart |
12. Jan 19:30 |
| 1899 Hoffenheim – RB Leipzig |
16. Jan 14:30 |
| RB Leipzig – Shakhtar Donetsk |
20. Jan 20:00 |
| Borussia Mönchengladbach – RB Leipzig |
23. Jan 14:30 |
| Feyenoord – RB Leipzig |
27. Jan 20:00 |
| RB Leipzig – Werder Bremen |
30. Jan 14:30 |
| Hamburger SV – RB Leipzig |
06. Feb 14:30 |
| RB Leipzig – Bayer Leverkusen |
13. Feb 14:30 |
| Eintracht Frankfurt – RB Leipzig |
20. Feb 14:30 |
| RB Leipzig – Bayern München |
27. Feb 14:30 |
| SV Elversberg – RB Leipzig |
02. Mar 19:30 |
| RB Leipzig – FC Schalke 04 |
06. Mar 14:30 |
| FC Augsburg – RB Leipzig |
13. Mar 14:30 |
| RB Leipzig – Union Berlin |
20. Mar 14:30 |
| RB Leipzig – SC Freiburg |
03. Apr 13:30 |
| FSV Mainz 05 – RB Leipzig |
10. Apr 13:30 |
| RB Leipzig – 1. FC Köln |
17. Apr 13:30 |
| Borussia Dortmund – RB Leipzig |
24. Apr 13:30 |
| RB Leipzig – SC Paderborn 07 |
08. May 13:30 |
| VfB Stuttgart – RB Leipzig |
15. May 13:30 |
| RB Leipzig – 1899 Hoffenheim |
22. May 13:30 |
